Not sure what you mean by "straight 600" and "toothy 600"? Not knowing that, I would say that it's one of those things you'd have to experiment with, and figure out what works best for you. As most things with building/finishing knives, there's no single, exact methodology that is gona give each person the results they seek.
What I do is hand sand/finish as I normally would, and use the hand block as the final finish. I always fully finish a blade prior to installing a guard or bolsters.....that way the finish is smooth and even at the blade/guard juncture. For me, any time I've tried to do the final finish on a blade with a guard/bolster in place, it never works out..... generally I get "fish hooks" just in front of the guard/bolsters..... so I don't do that anymore.