I’ll answer but with the caveat that the following is strictly my opinion, what works for you very well could be different.
First “Damascus” is just steel. I say that meaning that there are no magical properties, and for me I treat it like one or the other parent steels.
Second “Damascus” encompasses an extremely wide range of materials. To answer the question with the most confidence, I personally would need to know the parent metals.
Third, and quite frankly the most important for myself would be the material thickness. 98% of my knives are made from .120 or thinner stock (stock removal). Being that thin I rough grind the profile, drill and/or do any other machining then I heat treat and grid the bevels and refine the profile post heat treat. On the rare occasion I do anything thicker I will occasionally grind the bevels about 75% leaving roughly .050 on the edge. Not an exact science, it just makes the post heat treat grinding a touch easier.
Bottom line from my bench is this. Either way you choose to go there are hundreds not ways prior and hundreds of ways post, to ruin your piece. This particular decision won’t likely make or break the entire project.
Just my two cents.