I hate to tell you, but if it's 1045 and pure nickel....looks is about all it will be good for. Nickel is non-hardenable, and 1045, as quenched, is only going to yield a Rc hardness of around 55-56.
Even if the individual who produced the damascus did an outstanding job, with no damage done due to poor welding technique, it's still something that I would only use for bolsters, guards, or other "hardware". My guess would be that any knowledgeable bladesmith would only mix those two materials with the purpose of hardware in mind.