Hi Randy!
My recommendation is that there are a lot less troublesome things to use when making damascus. 52100 reacts very poorly to overheating, which is exactly what will take place when forge welding it. I've used it in a number of San-Mai blades, but I had to work out a whole new set of methodologies for almost ever step after forging, to get it close to the performance of my standard mix of 1080/15N20. Forged carefully, 52100 is currently my favorite mono steel....but it's a lot like 5160 in that it doesn't play well with others.
One of the biggest issues with using 52100 in a damascus mix comes during heat treating. There are very few other alloys with similar characteristics, and most of the time a damascus blade made with 52100 in the mix will exhibit severe warping during hardening on the milder side of things, and more often then not, you will get cracks and delaminations due to the stresses.
If you have your heart set on using 52100 in damascus, just be prepared...it's going to cause grief, and very likely you will have to change things in various steps of the process to make it come out what I consider "usable".....at least in comparison to a 1080/15N20 mix.