Jason,
I don't make folders personally but epoxy and pins/fasteners are used on almost all knives I know of. There are a few with take apart set ups that don't.
One of the main reasons for epoxy is to seal out moisture from under the scales.
I also epoxy the liners as well for this reason.
I use the superglues for a fill in while sanding mostly.
The knife in question is a shadow pattern toothpick with giraffe bone. I figured it wouldn't hurt the bone to be glued to the stainless liners, in case it wanted to crack, etc. Put a thin layer of epoxy in there, seems to be working well so far. I still have a little bit of handle shaping to do, then the pin peening.